Abstract

DRESS Syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is defined as a several symptoms and signs that appear as an a result of a delayed hypersensitivity reaction mediated by T lymphocytes to certain drugs included anticonvulsants, non-steroidal antiinflammatory drugs (NSAIDs), antibiotics and antiretrovirals among others, with low prevalence but a significant mortality (10%). Clinical features include fever, skin rash and eosinophilia, sometimes accompanied by decrease in liver or kidney function. We are presenting a case report of DRESS syndrome in 47 year old female, who developed fever, rash and facial edema due to lamotrigine. Early diagnosis and treatment led to her rapid recovery. This case is presented to highlight the importance of early detection of uncommon severe syndrome.

Keywords

fever, rash, DRESS syndrome, drugs, lamotrigine