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Hypomagnesemia at admission in ICU associated with complications in preeclampsia with severity criteria

Journal of Anesthesia & Critical Care: Open Access
Blanca Estela Herrera Morales,<sup>1</sup> Lyz Erandyn Rodriguez Hernandez,<sup>1</sup> Juan Lara Cruz,<sup>1</sup> José Alfredo Cortés Munguía,<sup>1</sup> Moises Moreno Noguez,<sup>2</sup> Nancy Allin Canedo Castillo,<sup>3</sup> Lidya Angélica Plascencia Zurita,<sup>4</sup> Luis Rey García Cortés,<sup>5</sup> Victoria Ortega López<sup>1</sup>


Background: Severe preeclampsia is a multifocal syndrome recognized by hypertension and proteinuria of recent onset after the 20 WG. It is defined as blood pressure levels greater than 160/110 mmHg associated with hypertensive encephalopathy, creatinine greater than 1.1 mg/dl, AST or ALT greater than 70 mg/dl or twice its previous value, LDH > 600 mg/dl, total bilirubin greater than 1.2 mg/dl at the expense of indirect bilirubin. Affecting between 3 and 10% of pregnancies, it is one of the leading causes of maternal death in the world. 
Objective: To estimate the association of magnesium levels as a factor for the development of complications in patients with severe preeclampsia.
Methods: Observational, prospective, longitudinal, and analytical study. A total of 56 patients from a second-level hospital with severe preeclampsia criteria were included, and serum magnesium measurements were taken at admission, 12 hours and 24 hours. Descriptive and analytical statistics were obtained using measures of association with 95%
CI, Cox proportional hazards.
Results: Patients admitted to the ICU had greater neurological symptoms with low magnesium levels, in addition to complications such as HELLP syndrome in 25% and eclampsia in 7.1%, which did not show significant differences. Conclusion: The application of magnesium sulfate causes changes in the delay and decrease of signs and symptoms. The effects on clinical variables, history, and complications with hypomagnesemia justify the administration of magnesium sulfate as the ideal treatment for neurological involvement in preeclampsia.


Hypomagnesemia, HELLP syndrome, Eclampsia