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Evaluation of the efficacy of a TCA medium peeling procedure combined with skin biorevitalization in face rejuvenation: a case series


Background: Aging is triggered by both intrinsic and external factors. Although chemical peels with trichloroacetic acid (TCA) are used to reduce wrinkles and hyperpigmentation, they cannot help to enhance the other factors that contribute to overall skin quality.
Objective: The aim of this case series was to compare the efficacy of 15% TCA peel alone versus a combination of NCTF®135HA injection and 15% TCA for face rejuvenation.
Methods: Six patients were treated on each side of their face with 15% TCA combined or not with NCTF®135HA. Each patient was subjected to one session of peeling on both sides of the face followed by three sessions of NCTF®135HA injections, on only one randomized side of the face, with an interval of two weeks between each treatment. Skin aging measures were assessed before and after treatments (D0 and D45).
Results: At D45, clinical scoring demonstrated a significant difference in reducing the lower face sagging score, increasing skin hydration, and improving skin homogeneity on the side treated with NCTF®135HA combined with peeling compared to the side treated with peeling alone. There is a tendency for improvement in Crow’s feet only on the side treated with both peeling and NCTF®135HA, compared to the side treated with peeling
alone. Both the evaluator and the patient reported a greater improvement on the side of the face treated with 15% TCA + NCTF®135HA on the Global Aesthetic Improvement Scale (GAIS).
Conclusions: The addition of NCTF®135HA to 15% TCA chemical peel application significantly enhanced the peeling effect on skin aging features, this improvement was perceived by both subjects and the physician.


biorevitalization, skin ageing, hyaluronic acid, aesthetic medicine