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Endometriosis: pathophysiology, market analysis, and research landscape


Abstract

Endometriosis is a chronic gynecological condition affecting millions of women globally, significantly impacting their quality of life and reproductive health. Characterized by the presence of endometrial-like tissue outside the uterus, this condition leads to inflammation, chronic pelvic pain, infertility, and compromised organ function. Despite its prevalence, there is no definitive cure for endometriosis, and current treatments primarily focus on managing symptoms and preserving fertility. Surgical interventions, such as laparoscopic excision, remain central to managing severe cases. The increasing incidence of endometriosis and the limitations of existing treatments have driven substantial research efforts toward more effective therapies, including personalized medicine approaches. The global endometriosis treatment market, valued at approximately USD 1.3 billion in 2022, is projected to reach USD 3.21 billion by 2030, driven by advancements in diagnostics and novel therapeutics.41,29,7 Key market players include AbbVie and Pfizer, with significant contributions from ongoing clinical trials exploring innovative treatments such as Bayer’s P2X3 receptor antagonist. This review examines the pathophysiology of endometriosis, evaluates current therapeutic strategies, and highlights emerging research trends, providing a comprehensive perspective on the future of endometriosis management.

Keywords

tissue engineering, chronic pelvic pain, infertility, laparoscopic excision, personalized medicine, diagnostic techniques, therapeutics, clinical trials, pharmaceutical industry, hormonal therapy, surgical interventions, non-invasive diagnostics, biomarkers, inflammatory response, estrogen regulation, novel pharmacological agents, aromatase inhibitors

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