Abstract

Screen-printing technology has emerged as an efficient method for constructing highly sensitive and accurate electrochemical sensors, with applications across various fields. This unique combination of sensitivity, selectivity, and stability, along with miniaturization, portability, and on-site, in situ detection, makes screen-printed electrodes a valuable tool in sensor design. With these advantages, screen-printed electrode-based sensors have become increasingly popular in pharmaceutical and biological analysis, for detecting trace biomolecules. In this study, a novel, polymer-modified screen-printed gold electrode electrochemical sensor has been developed for detecting low clinical concentrations of doxorubicin. The sensor modification, based on a Nano composite of reduced graphene oxide decorated with gold nanoparticles embedded in a Nafion matrix, has not been previously reported in the literature. Using cyclic voltammetry, the sensor achieved accurate quantification of doxorubicin, with a linear concentration range of 1.5 to 22.1 µM and a detection limit of 11.462 µM under optimal conditions. The sensor’s high surface area, functionalization capability, wide linear range, high sensitivity, and rapid response indicate its potential for practical applications in anticancer drug detection.

Keywords

electrochemical sensor, screen-printed gold electrode, doxorubicin, anticancer medication, monitoring