Analyze the effects of A paniculata leaf extract in methanol on Candida albicans RFG1 gene expression
- International Journal of Molecular Biology: Open Access
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P Sagadevan,<sup>1</sup> M Raghunath,<sup>1</sup> M Nagarajan,<sup>1</sup> M Kannan,<sup>1</sup> N Sribala,<sup>1</sup> Charles Paul,<sup>1</sup> V Senthil kumar,<sup>2</sup> Aruna Devi,<sup>1</sup> P Kavipriya<sup>1</sup>
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Abstract
The gene expression studies showed decreased level of Rfg1 gene expression in C. albicans upon treatment with methanolic leaf extracts of A. paniculata. However, similar molecular studies on pure compounds from this plant may give strong evidences about the pharmacological potential of the plant and thus can be formulated as an effective drug for the treatment of infections caused by C. albicans. The bioassays on antifungal activity of the methanolic leaf extract of A. paniculata showed inhibitory effects against human pathogen C. albicans
Keywords
Rfg1, A. paniculata, C. albicans
