Abstract

Alzheimer’s disease (AD) is a growing social, economic, and medical crisis, affecting millions and contributing significantly to healthcare costs globally. As the most common form of dementia, AD is characterized by progressive neurodegeneration. The neuron and synaptic loss that occurs in the diseased brain leads to several adversities such as cognitive decline, memory loss, learning disabilities, and mood disturbances. Given the irreversible nature of neural death in AD, therapeutic strategies focusing on neurogenesis and synaptogenesis offer very promising avenues for intervention, as they can replace rather than repair neurons and synapses. More specifically, these strategies facilitate the formation of new neurons in the brain and the creation of new synaptic connections between neurons. In particular, stem cell therapy presents itself as a prospective solution by promoting the regeneration of depleted neuronal circuitry, addressing the root cause of neurodegeneration. It is vital to understand the mechanisms underlying AD progression and explore innovative treatment options based upon them in order to mitigate the devastating impact of this disease. This report will highlight the budding potential of stem cell therapy mechanisms as a practical approach to treating the catastrophic affliction that is AD.

Keywords

alzheimer’s disease, genetic mutation, degeneration, stem cells, therapy