Lépi, the traditional fabric of the Sudano-Sahelian peoples—particularly in Cameroon and Guinea—is undergoing a major transformation through its gradual integration into contemporary fashion. This article explores the technical, symbolic, and aesthetic characteristics of this artisanal textile, while offering a contextualized analysis of its current uses by African designers. Through a comparative and creative approach, it highlights the stylistic potential of Lépi in ready-to-wear fashion, haute couture, and accessories, drawing on recent research and field initiatives. The study also emphasizes the economic and cultural stakes involved in its revalorization: structuring local value chains, cultural diplomacy, and the development of creative industries. This work thus proposes a new textile grammar, where tradition and innovation meet to position Lépi within the future of African fashion design.