Abstract

This case report evaluates the efficacy of a high-intensity parallel beam ultrasound device alone versus its combination with liquid type polycaprolactone (PCL) for facial wrinkle treatment. The study aims to determine whether the combined approach enhances outcomes through synergistic effects on multiple tissue layers. A case study was conducted, with the left side treated using ultrasound alone and the right side treated with ultrasound plus liquid type PCL. The ultrasound treatment involved 300 lines (150 per side) at 3.4 J. On the right side, 1 cc of liquid type PCL was injected subdermally. Assessments were conducted at baseline, day 14, day 30, and day 90 using the Modified Fitzpatrick Wrinkle Scale, Allergan Infraorbital Scale, and Global Aesthetic Improvement Scale. By day 90, the combination treatment improved MFWS from 1.5 to 0 and AIS from 2 to 0, while ultrasound alone improved MFWS to 1 and AIS to 1. Investigator and patient GAIS ratings confirmed greater and faster improvements on the right side, with the patient reporting enhanced skin texture, brightness, and finer pores. The combination of ultrasound and liquid type PCL resulted in significantly greater improvements in nasolabial wrinkle severity and infraorbital volume loss compared to ultrasound alone, suggesting a synergistic effect.

Keywords

high-intensity parallel beam ultrasound, liquid type polycaprolactone, PCL biostimulator, facial rejuvenation, wrinkle improvement