Herpes zoster ophthalmicus despite shingrix immunization
- Advances in Ophthalmology & Visual System
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Len V Koh, Chad E Gosnell, Allison C Makadia, Virginia O Bice, Kyle P Criswell
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Abstract
Background: Herpes zoster ophthalmicus (HZO) is a reactivation of the varicella-zoster
virus causing serious ocular and systemic complications, particularly in individuals with
declining immunity.
Case report: A 74-year-old male with a history of various chronic conditions was referred
to an eye clinic due to herpes zoster affecting his right forehead and eye. Initial treatment
included acetaminophen-hydrocodone, valacyclovir, and ofloxacin, with hypotensive agent
added to manage elevated intraocular pressure. Follow-up visits showed improvement in
lid swelling and eye pain, although his visual acuity initially worsened before eventually
improving to near complete resolution, with corneal edema resolving with topical steroid
and IOP stabilizing. The patient’s treatment regimen was adjusted accordingly, with
instructions to return for continued care until resolution.
Conclusion: This case report highlights an unusual occurrence of HZO in an
immunocompetent patient who had received Shingrix, emphasizing the need for awareness,
early diagnosis, antiviral therapy, and tailored co-management approaches for effective
care.
Keywords
herpes zoster ophthalmicus, shingles, shingrix, corneal edema, intraocular pressure, diabetes mellitus