Abstract

Introduction: Post-inflammatory hyperpigmentation (PIH) follows skin inflammation or injury and is especially common in individuals with colour of skin. This study aimed to evaluate the efficacy of New Liftactiv B3 Melasyl for acne-induced PIH in female subjects over three months, through a randomized, double-blind, placebo-controlled study. Materials and methods: one hundred and twelve females with mild to moderate PIH were enrolled and randomized to Group A (New Liftactiv B3 Melasyl) and Group B (Placebo) and subjects were used the serum twice daily for 3 months. The main outcome measures were improvement in post acne hyperpigmentation index (PAHPI) and Investigator Global Assessment (IGA) scores, improvement in skin attributes, improvement in parameters using spectrophotometer, corneometer, tewameter, Antera, and VISIA CR. Evaluations were performed at baseline, months one, two, and three. Results: Group A showed a statistically significant PAHPI reduction (p<0.001), with decreases of 11.69%, 35.98%, and 43.48% at months 1, 2, and 3, respectively with distinct visual improvement observed by month 1. Similar significant improvement in IGA scores, with reductions of 19.73%, 55.10%, and 59.86% at months 1-3 (p<0.001) was observed. Group A exhibited twice the improvement as Group B at months 2 and 3, highlighting its superior efficacy. At the end of 3 months, New Liftactiv B3 Melasyl was found to be well tolerated by all participants. Group A demonstrated pigmentary spot density reduction, confirmed by spectrophotometer and Antera. Improvements in pigmentation, clarity, and complexion, with lighter spots, reduced imperfections, and even tone were also observed. Conclusion: New Liftactiv B3 Melasyl demonstrated statistically significant improvements in multiple skin parameters, with early differentiation from month 1, and sustained efficacy through month 3. These findings show the efficacy and good tolerance of New Liftactiv B3 Melasyl for treating acne-induced PIH.

Keywords

post inflammatory hyperpigmentation, acne, spots, PIH, SoC, depigmentation