Experiments were conducted with four cotton-based fabrics to determine friction against human skin under different wetting conditions and loads. The friction of mixed fabrics is higher than that of 100% cotton fabrics. On both water-wetted and cream-treated skin, the friction of the fabrics is approximately 1.5 to 2 times greater than that on dry skin. Hygroscopic fabrics experience higher friction when the tension is increased. Friction decreases with increasing tension in fabrics where the picks per inch (PPI) exceed the ends per inch (EPI). On cold cream-treated skin, friction is not significantly affected by the tension in tightly woven fabrics.