Abstract

Breast reconstruction is a multidisciplinary field at the intersection of surgical oncology, plastic surgery, and tissue engineering, aiming to restore form, symmetry, and patient well-being following breast tissue removal. The field has evolved from relying solely on autologous tissue and silicone implants to exploring regenerative strategies involving stem cells, bioprinted scaffolds, and synthetic meshes that support integration and vascularization. This review aims to synthesize current advances in breast reconstruction technologies, discuss clinical adoption and market trends, and highlight how bioengineering innovations transform traditional reconstructive options.In addition to evaluating marketed and investigational products, this paper briefly considers how the biology of healthy and diseased breast tissue impacts reconstructive performance and how diagnostic delays influence reconstruction planning. By linking tissue-level pathophysiology to reconstructive outcomes, the paper underscores the need for precision-engineered solutions that adapt to diverse anatomical and clinical challenges. 

Keywords

breast reconstruction, tissue engineering, regenerative medicine, autologous fat grafting, 3D bioprinting, adipose-derived stem cells, implant-based reconstruction, acellular dermal matrix, patient-reported outcomes