Abstract

Langerhans cell histiocytosis (LCH), a condition that mainly affects the skin and bones, is a rare disorder caused by the accumulation of histiocytes in different tissues. The resultant cutaneous lesions can be highly variable in appearance, potentially leading to misdiagnosis as other common dermatoses. In this report, we describe the case of a 4-month-old boy who presented with a generalized vesiculopustular itchy skin rash that had persisted for 3 months. In addition, the patient had a wide spectrum of cutaneous lesions, the pattern of which, to the best of our knowledge, has not been previously reported in the literature for LCH. On the basis of the typical clinical findings, the patient was ultimately diagnosed with LCH. This case highlights the importance of considering LCH in the differential diagnosis, even during the neonatal period, and of distinguishing this condition from other common neonatal dermatoses.

Keywords

dermatology, pediatric dermatosis, histiocyte, cutaneous lesion, langerhans cells