Abstract

Sarcopenia is a common geriatric disease characterized by the decline of muscle strength, mass, and function. Its pathogenesis is complex and there is no unified conclusion. Establishing appropriate mouse models is fundamental to studying this disease. Currently, methods for constructing sarcopenia mouse models include induced injection, aging models, muscle atrophy models, and transgenic models. Each model has its applicable conditions and limitations. Therefore, through a literature review of sarcopenia, this paper summarizes the modeling methods and mechanisms of sarcopenia in mice and provides an overview, aiming to provide references for related research.

Keywords

sarcopenia, animal model, skeletal muscle aging, modeling method