Abstract

Recent advancements in stem cell biology have accelerated the development of stem cellbased therapies for periodontal tissue regeneration. Twenty-six human clinical studies performed across 10 countries have reported on the use of mesenchymal stem cells (MSCs) for periodontal regeneration, making this approach one of the most thoroughly explored in oral and maxillofacial medicine. Among the various MSC types, dental stem cells (DSCs), including dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), and gingival MSCs (GMSCs), have shown advancements due to their accessibility, high proliferation rates, and strong osteogenic potential. Numerous studies have demonstrated the ability of these cells to reduce inflammation, enhance bone regeneration, and restore periodontal tissues. However, continued research and larger clinical trials are needed to fully understand their mechanisms and learn their potential.

Keywords

stem cell biology, periodontal tissue regeneration, oral and maxillofacial medicine, bone regeneration, clinical studies, regenerative dentistry