Abstract

Objective: The neutrophil-to-lymphocyte ratio (NLR) is increasingly utilized as a practical and cost-effective parameter for evaluating systemic inflammation and predicting the prognosis of various diseases. This study aimed to compare the effects of low-flow and high-flow anesthesia on hemodynamic parameters and NLR levels. Methods: With ethics committee approval, this retrospective study included 50 patients who underwent tympanoplasty or myringoplasty. Patients receiving high-flow anesthesia (Group Y) at 3 L/min and those receiving low-flow anesthesia (Group D) at 0.75 L/min were included. Data on age, sex, weight and hemodynamics were obtained from anesthesia records. NLR was calculated from preoperative and postoperative complete blood count results. Sevoflurane consumption was also determined. Results: The groups did not differ significantly in terms of age, sex, body mass index, anesthesia duration, and complication rates. A significant postoperative increase in NLR was observed in Group Y, but not in Group D. Intergroup comparison revealed that postoperative NLR was significantly lower in Group D compared to Group Y. Sevoflurane consumption was also significantly lower in the low-flow group. Conclusion: Low-flow anesthesia may offer environmental and economic advantages by reducing volatile anesthetic consumption. Furthermore, it may help attenuate the systemic inflammatory response, suggesting a potential clinical benefit in its use

Keywords

Low-flow anesthesia; High-flow anesthesia; Neutrophil-lymphocyte ratio; Systemic inflammatory response; Myringoplasty; sevoflurane