Migraine is considered a multifactorial disease, the trigger of which is unknown. Hypothesis of the occurrence of migraine: in genetically predisposed individuals, long-term negative factors (chronic stress) cause - through cortico-nuclear pathways - excessive constriction of the pupils, which is manifested by significant activation of the parasympathetic nervous system. Constricted pupils (reduction in light flux) through the optic-vegetative system trigger pathological biochemical processes in the body, which leads to a deterioration in the physical and psychological conditions of patients with migraine. 

It is proposed to introduce medical pupil dilation into the treatment protocol for migraine (and all somatic and mental illnesses) in order to eliminate the negative impact on the body of an overly activated parasympathetic nervous system