Abstract

Introduction: Depression and chronic pain are frequently interconnected conditions that significantly impair functionality, well-being, and quality of life. Their relationship is bidirectional, mediated by shared neurobiological mechanisms and psychosocial factors such as catastrophizing, social isolation, and hopelessness, demanding therapeutic approaches that transcend the traditional biomedical model. Objective: To investigate, through an integrative literature review, the main therapeutic strategies used in the simultaneous management of chronic pain and depression, with emphasis on non-pharmacological interventions that foster functional recovery and overall patient well-being. Methods: A systematic search was conducted in PubMed and SciELO for publications from 2019 to 2024; after applying inclusion and exclusion criteria, 18 articles were qualitatively analyzed. Results: The most frequent therapies included Cognitive-Behavioral Therapy (CBT), Mindfulness-Based interventions, Acceptance and Commitment Therapy (ACT), as well as integrated programs combining physiotherapy and online modalities. Studies consistently reported reductions in pain intensity, functional interference, depressive and anxiety symptoms, and catastrophizing, along with increased pain acceptance and patient autonomy. Discussion: Findings reinforce that integrated therapeutic strategies yield lasting benefits, particularly when tailored to the patient’s psychological and social profile. Both faceto-face and virtual formats of CBT and mindfulness-based approaches proved effective, broadening access to care; personalization, cognitive restructuring, and active patient engagement emerged as key elements for therapeutic success. Conclusion: Effective management of co-occurring depression and chronic pain requires an interdisciplinary, patient-centered approach. Non-pharmacological therapies, especially psychotherapeutic interventions — are essential to reduce suffering, restore function, and reclaim autonomy, supporting more integrative, humanized, and effective clinical practices in mental health and pain care.

Keywords

depression, chronic pain, cognitive-behavioral therapy, integrative therapies, mental health