Retrospective study on the effectiveness and safety of poly-L-lactic acid (PLLA-SCA) for skin flaccidity in the labia majora and mons pubis
- Obstetrics & Gynecology International Journal
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Dóris Hexsel,<sup>1</sup> Christine M Guarnieri,<sup>2</sup> Meire B Parada,<sup>3 </sup>Maria P Del Nero,<sup>4</sup> Ana CK dos Santos,<sup>1</sup> Vitor C Fabris,<sup>1</sup> Cristhine Kamamoto,<sup>5</sup> Rafael Tomaz Gomes,<sup>5</sup> Alessandra Nogueira<sup>5</sup>
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Abstract
Background: Poly-L-lactic acid (PLLA-SCA) is a biostimulator used for the treatment of sagging skin. In recent years, there has been a growing demand for dermatological procedures in the genital region, primarily attributed to the loss of firmness, which can be improved with PLLA-SCA injection.
Purpose: Evaluate the effectiveness and safety of PLLA-SCA for skin flaccidity in the labia majora and mons pubis.
Methods: This retrospective, single-arm, clinical trial involved the analysis of medical records from nine women who underwent treatment with PLLA-SCA for skin flaccidity on the labia majora and/or mons pubis. The endpoints included improvements in skin flaccidity, functional symptoms, and overall aesthetic appearance, which were assessed by independent investigators using the Global Aesthetic Improvement Scale (GAIS), as well as the frequency of adverse events. Clinical trial registration: NCT05940038.
Results: The participants were Caucasian women, with a median (p25-p75) age of 59 years (48–71). All underwent three PLLA-SCA sessions in the indicated region, using one vial per treatment session. Only two had previously undergone treatment with PLLA-SCA in other areas, and none had undergone any other treatment in the labia majora and mons pubis. The labia majora were treated in 78% of the cases, while 22% were treated in other external genital areas. GAIS evaluation showed improvement in 100% of the subjects, both in skin flaccidity and overall appearance. Regarding functional symptoms (e.g., discomfort in sports, difficulties in sexual intercourse, perception of flaccidity), 86% reported complete or partial improvement. Four patients (44%) experienced adverse events after the procedure (pain, hematoma, and hypersensitivity in the labia minora), however, all were mild and transient.
Conclusion: Procedures involving the injection of PLLA-SCA in the mons pubis and labia majora are well tolerated and effective for reducing flaccidity and enhancing skin firmness. Moreover, these procedures also have the potential to mitigate functional complaints associated with genital aging.
Purpose: Evaluate the effectiveness and safety of PLLA-SCA for skin flaccidity in the labia majora and mons pubis.
Methods: This retrospective, single-arm, clinical trial involved the analysis of medical records from nine women who underwent treatment with PLLA-SCA for skin flaccidity on the labia majora and/or mons pubis. The endpoints included improvements in skin flaccidity, functional symptoms, and overall aesthetic appearance, which were assessed by independent investigators using the Global Aesthetic Improvement Scale (GAIS), as well as the frequency of adverse events. Clinical trial registration: NCT05940038.
Results: The participants were Caucasian women, with a median (p25-p75) age of 59 years (48–71). All underwent three PLLA-SCA sessions in the indicated region, using one vial per treatment session. Only two had previously undergone treatment with PLLA-SCA in other areas, and none had undergone any other treatment in the labia majora and mons pubis. The labia majora were treated in 78% of the cases, while 22% were treated in other external genital areas. GAIS evaluation showed improvement in 100% of the subjects, both in skin flaccidity and overall appearance. Regarding functional symptoms (e.g., discomfort in sports, difficulties in sexual intercourse, perception of flaccidity), 86% reported complete or partial improvement. Four patients (44%) experienced adverse events after the procedure (pain, hematoma, and hypersensitivity in the labia minora), however, all were mild and transient.
Conclusion: Procedures involving the injection of PLLA-SCA in the mons pubis and labia majora are well tolerated and effective for reducing flaccidity and enhancing skin firmness. Moreover, these procedures also have the potential to mitigate functional complaints associated with genital aging.
Keywords
aging, labia majora, poly-L-lactic acid, mons pubis
