Abstract

Human skin, the largest organ of the body, exhibits a wide variety of types-oily, dry, combination, sensitive, and normal having each a distinct physiological and biochemical characteristics. Improving skin health requires individualized protection strategies that align with specific skin types, barrier functions, and environmental exposures. Among the growing concerns in dermatological sciences, climate change has emerged as a significant threat for keeping skin healthier. Rise in temperatures, UV radiation, pollution, and humidity fluctuations are key concerns which contributes in maximum trans epidermal skin water loss, oxidative stress, premature aging, and inflammation, disproportionately affecting especially sensitive and dry skin types. Recent dermatological studies revealed how nurturing the skin deeper with using skin-care ingredients by awaking ourselves to understand how active dermal ingredient like hyaluronic acid (HA) interact with skin at the molecular level. However, their topical bioavailability and molecular interactions with skin receptors and enzymes vary significantly, necessitating computational modeling to predict efficacy. To elucidate these interactions, molecular docking studies have been conducted targeting skin-associated proteins such as CD44 (the primary receptor for HA). Docking simulations revealed strong binding affinities between HA and CD44 domains, affirming HA’s skin-adhesive and moisture-retaining properties. Hence, protecting the skin amidst environmental stressors requires a personalized, science-backed approach, incorporating both preventive (e.g., UV shields, barrier creams) and active like Hyaluronic acid (HA) and vitamin, Vitamin E based strategies. Climate-resilient skincare formulations are needed to get prepared by molecular docking and biochemical interpretations to offer promising personalized skin-care regime and skin-therapeutic tools.

Keywords

hyaluronic acid, vitamin C, cosmeceutical approach, autodoc, ligplot+ diagram