Abstract

A 44-year-old Yemeni female with a 2-year history of pemphigus vulgaris managed with oral prednisolone, azathioprine, and topical steroids presented with a 3-month history of an exophytic growth in the anogenital area. Clinical examination revealed a cauliflower- like exophytic mass involving the perianal region, extending to the labia majora and pubic region. Additionally, a skin-colored papilloma was noted on the left lacrimal caruncle, consistent with human papillomavirus infection. Conjunctival papilloma in association with giant condyloma acuminatum has previously been reported only once. The patient underwent successful electrosurgical excision followed by a 30% trichloroacetic acid peel. Four weeks of oral acitretin therapy and topical imiquimod 3.75% cream yielded moderate improvement. To our knowledge, this represents the first reported case of a female patient with pemphigus vulgaris on immunosuppressive therapy presenting with a coexisting caruncular papilloma.

Keywords

condyloma, conjunctival papilloma, Yemeni female, pemphigus vulgaris, immunosuppressive therapy