Abstract

Age-related macular degeneration (AMD) is a leading cause of visual impairment, with the dry form often progressing to geographic atrophy due to retinal pigment epithelium (RPE) loss. Fundus autofluorescence (FAF) provides a non-invasive window into RPE health and disease progression. We report a 73-year-old man with a gradual, painless visual decline, in whom wide-field FAF revealed a distinctive cloverleaf pattern of hypoautofluorescence corresponding to areas of atrophy, with surrounding reticular changes suggestive of RPE dysfunction. This case highlights the value of FAF in identifying characteristic atrophic patterns and underscores its role in monitoring disease progression in dry AMD in a clinically meaningful and patient-friendly manner

Keywords

ARMD, autofluorescence, geographical atrophy, retinal pigment