This study investigates the impact of fabric shrinkage on marker efficiency for long-sleeve women’s shirts and compares the performance of four CAD systems: Gerber, Lectra, Gemini, and CLO 3D. An experimental and comparative research design was adopted, applying a controlled shrinkage value of 3% (2% lengthwise and 1% widthwise) to garment patterns. Marker layouts were developed under identical conditions across all systems, and efficiency values were analyzed. The results show that marker efficiency improved in all systems when shrinkage was applied. Gemini achieved the highest efficiency (89.83%), followed by Lectra (89.03%), Gerber (89.00%), and CLO 3D (88.48%). Although the improvements were marginal, they were consistent across all platforms. The findings highlight the importance of incorporating shrinkage in marker planning to enhance fabric utilization and support sustainable apparel manufacturing. The study employed descriptive and comparative statistical analysis to evaluate software performance under controlled shrinkage conditions.