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Borderline regions in tissue diagnostics and cutoffs in molecular diagnostics: distinguishing reader uncertainty from analytical threshold uncertainty

: Open Access Journal of Science
: Jesse Albert Canchola,¹ Valerie Cousineau,² Brahian Cano Urrego³

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Keywords

tissue diagnostics, molecular diagnostics, equivocal zone, cutoff analysis, cycle threshold, method comparison, pathologist reader study, PPA, NPA, OPA, limit of detection, diagnostic validation

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