Abstract

The high incidence of surgical site infections (SSI) is a serious problem in developing countries and has an impact on public health. Therefore, it was proposed to evaluate the antimicrobial activity of different topical formulations based on M. indica seed extract, both in vitro and on surgical site infections of patients admitted to the Hospital Central de Maracay (Aragua-Venezuela). Different topical formulations were evaluated in vitro through various assays. Subsequently, patients diagnosed with surgical site infection were selected and divided into two groups: the first (A) received treatment with the topical extract-based formulation, and a second (B) received a placebo. Both groups received their respective antibiotic therapy. All concentrations showed in vitro antimicrobial activity in both certified and wild strains. In patients, Group A showed an earlier resolution of wound inflammation and discharge with 80% of patients having no signs of inflammation (phlogosis) by day 6 (p=0.0003). Wound healing was faster in the experimental group, with 80% granulation by day 6 and 100% re-epithelialization by day 10, compared to 50% in the control group (p<0.005). The healing time was shorter in the experimental group (6.0±0.9 days) compared to the control one (7.6±1.1 days). The cream formulated with 15% mango seed extract proved to be an efficient adjuvant for the treatment of patients with this type of infection; since it improved the times for granulation, re-epithelialization, and overall wound healing.

Keywords

mango seed, postoperative infections, natural products, re-epithelialization, wound healing, antimicrobial